Principal Research Scientist I, Biologics Screening - Discovery Biotherapeutics

Company: AbbVie
Location: San Francisco
Posted on: March 27, 2026

Job Description:

Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on X , Facebook , Instagram , YouTube , LinkedIn and Tik Tok . Job Description Discovery Biotherapeutics and Genetic Medicine (BGM) at AbbVie is seeking a highly motivated Principal Scientist to join the Biotherapeutics group at the AbbVie Bay Area (ABA) site based in South San Francisco, CA. This role seeks a skilled and experienced individual to contribute to and lead therapeutic programs, focusing on biophysical screening to advance biotherapeutics from early exploration through lead identification and optimization. Close partnerships with Oncology will be required to drive transformative ideas to the clinic. The ideal candidate must possess expertise in high-throughput biologics screening and characterization methods (e.g. ELISA, FACS, BLI, SPR, etc.) and have a solid foundation in protein sciences and antibody discovery with a proven ability to work effectively on cross-functional teams. Responsibilities Lead from the lab to advance large molecule biologics projects from exploratory to optimization stages and drive Go / No Go decisions. Effectively partner with functional and therapeutic areas to achieve project objectives. Identify and integrate cutting-edge technologies and methodologies into screening and assay development, anticipating future trends in drug discovery. Multitask and work within timelines while maintaining a high level of productivity. Supervise 1-2 scientists, evaluate team performance, and is accountable for the effective performance of team Qualifications BS, MS, or PhD with typically 14 (BS), 12 (MS), or 6 (PhD) years of relevant experience. Experience with biologics, monoclonal antibodies and/or protein therapeutics. Experience advancing Discovery programs from exploratory to candidate nomination Independently develop and execute biosensor and cell-based platforms to evaluate panels of antibody biotherapeutics. Implement high-throughput epitope binning for large panels of monoclonal antibodies and develop deep knowledge of antibody sequence/function relationships. Evaluate and integrate biomolecular interaction technologies (e.g., SPR) to guide therapeutic candidate selection recommendations. Expert in biophysical characterization instrumentation and methodologies such as SEC, MS, HDX-MS, X-ray crystallography, DSF, DLS, etc. Challenge the status quo and onboard cutting-edge technologies to drive discovery and innovation. Excellent attention to detail, record keeping, and organization. Excellent communication, presentation, and collaboration skills. Preferred Qualifications Antibody sequence and structure knowledge. Structure-based molecular modeling and applications with AI/ML and integrating complex datasets to drive data-based decisions. CRO and external partner management. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law: The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees. This job is eligible to participate in our short-term incentiveprograms. This job is eligible to participate in our long-term incentiveprograms. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

Keywords: AbbVie, Tracy , Principal Research Scientist I, Biologics Screening - Discovery Biotherapeutics, Healthcare , San Francisco, California